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Fusanori Yotsumoto Selected Research

Epidermal Growth Factor (EGF)

7/2018Association of Serum HB-EGF Value and Response to Chemotherapy in Patients with Recurrent Ovarian Cancer.
1/2017Antitumour Effects of Intravenous Administration of BK-UM, a Novel Inhibitor of HB-EGF, in Ovarian Cancer Therapy.
1/2017Serum Heparin-binding Epidermal Growth Factor-like Growth Factor (HB-EGF) as a Biomarker for Primary Ovarian Cancer.
7/2016Anti-tumor Effect of Intravenous Administration of CRM197 for Triple-negative Breast Cancer Therapy.
4/2015Warburg effect regulated by amphiregulin in the development of colorectal cancer.
10/2014Contribution of transcription factor, SP1, to the promotion of HB-EGF expression in defense mechanism against the treatment of irinotecan in ovarian clear cell carcinoma.
8/2014Pre-clinical study of BK-UM, a novel inhibitor of HB-EGF, for ovarian cancer therapy.
6/2012Regulatory mechanisms of the HB-EGF autocrine loop in inflammation, homeostasis, development and cancer.
11/2011A novel anti-human HB-EGF monoclonal antibody with multiple antitumor mechanisms against ovarian cancer cells.
7/2011Antitumor effects of CRM197, a specific inhibitor of HB-EGF, in T-cell acute lymphoblastic leukemia.
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Fusanori Yotsumoto Research Topics

Disease

34Neoplasms (Cancer)
05/2017 - 06/2005
17Ovarian Neoplasms (Ovarian Cancer)
07/2018 - 03/2007
3Triple Negative Breast Neoplasms
07/2016 - 12/2010
3Breast Neoplasms (Breast Cancer)
12/2010 - 01/2008
2Fibrosis (Cirrhosis)
01/2022 - 01/2020
2Inflammation (Inflammations)
02/2021 - 06/2012
2Chorioamnionitis
02/2021 - 01/2019
2Endometrial Neoplasms (Endometrial Cancer)
08/2019 - 07/2016
2Infections
01/2019 - 06/2012
2Lung Neoplasms (Lung Cancer)
01/2017 - 01/2008
2Brain Neoplasms (Brain Tumor)
02/2016 - 04/2015
2Carcinoma (Carcinomatosis)
10/2014 - 01/2011
2Atherosclerosis
06/2012 - 05/2006
2Neoplasm Metastasis (Metastasis)
10/2008 - 05/2006
1Endometriosis
01/2022
1Neuroblastoma
08/2015
1Carcinogenesis
08/2015
1Colorectal Neoplasms (Colorectal Cancer)
04/2015
1Hypoxia (Hypoxemia)
05/2013
1Wilms Tumor (Wilm's Tumor)
06/2012
1Chronic Disease (Chronic Diseases)
06/2012
1Adult T-Cell Leukemia-Lymphoma (Leukemia Lymphoma, T Cell, Acute, HTLV I Associated)
04/2012
1Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL)
07/2011
1Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
07/2011
1Ovarian Cysts (Ovarian Cyst)
07/2011
1Ascites
01/2011
1Pancreatic Neoplasms (Pancreatic Cancer)
11/2010
1Stomach Neoplasms (Stomach Cancer)
08/2010
1Polyps
08/2010
1Cholangiocarcinoma
01/2008
1Glioblastoma (Glioblastoma Multiforme)
01/2008
1Melanoma (Melanoma, Malignant)
01/2008
1Renal Cell Carcinoma (Grawitz Tumor)
01/2008
1Prostatic Neoplasms (Prostate Cancer)
01/2008

Drug/Important Bio-Agent (IBA)

26Heparin-binding EGF-like Growth Factor (HB-EGF)IBA
07/2018 - 05/2006
19Epidermal Growth Factor (EGF)IBA
07/2018 - 05/2006
18Heparin (Liquaemin)FDA LinkGeneric
07/2018 - 05/2006
18Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
07/2018 - 05/2006
12CRM197 (non-toxic variant of diphtheria toxin)IBA
01/2017 - 05/2006
8Biomarkers (Surrogate Marker)IBA
02/2021 - 12/2006
8Antineoplastic Agents (Antineoplastics)IBA
07/2018 - 10/2008
8ErbB Receptors (EGF Receptor)IBA
01/2017 - 05/2006
8LigandsIBA
01/2017 - 05/2006
4Paclitaxel (Taxol)FDA LinkGeneric
05/2017 - 03/2009
3MicroRNAs (MicroRNA)IBA
02/2021 - 06/2012
3Cisplatin (Platino)FDA LinkGeneric
05/2017 - 11/2010
3chondroitin sulfate proteoglycan 4IBA
02/2016 - 01/2014
3AmphiregulinIBA
04/2015 - 01/2008
3Biological ProductsIBA
06/2012 - 12/2006
3Proteins (Proteins, Gene)FDA Link
06/2012 - 02/2011
3AntigensIBA
03/2007 - 06/2005
2Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2020 - 10/2008
2Glucose (Dextrose)FDA LinkGeneric
01/2019 - 07/2013
2IntegrinsIBA
04/2015 - 01/2014
2Monoclonal AntibodiesIBA
11/2011 - 03/2009
2Phosphotransferases (Kinase)IBA
02/2011 - 08/2010
1CytokinesIBA
01/2022
1Ribosomal DNA (rDNA)IBA
02/2021
1Ethanol (Ethyl Alcohol)IBA
01/2020
1PlatinumIBA
08/2019
1taxaneIBA
08/2019
1L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA
01/2019
1C-Reactive ProteinIBA
01/2019
1Indicators and Reagents (Reagents)IBA
07/2018
1Nucleic AcidsIBA
05/2017
1Pharmaceutical PreparationsIBA
05/2017
1Docetaxel (Taxotere)FDA Link
07/2016
1DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)IBA
08/2015
1Irinotecan (Camptosar)FDA LinkGeneric
10/2014
1Sp1 Transcription FactorIBA
10/2014
1EnzymesIBA
07/2013
1AngiopoietinsIBA
05/2013
1NF-kappa B (NF-kB)IBA
06/2012
1alpha Subunit Hypoxia-Inducible Factor 1IBA
06/2012
1Immunologic Factors (Immunomodulators)IBA
06/2012
1Transcription Factor AP-1 (Transcription Factor AP 1)IBA
06/2012
1ABT-737IBA
04/2012
1Bevacizumab (Avastin)FDA Link
07/2011
1Doxorubicin (Adriamycin)FDA LinkGeneric
07/2011
1DisintegrinsIBA
02/2011
1AcidsIBA
02/2011
1Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA
02/2011
1Metalloproteases (Metalloproteinases)IBA
02/2011
1SuspensionsIBA
01/2011
1Matrix Metalloproteinase 1 (Interstitial Collagenase)IBA
01/2011
1Matrix Metalloproteinase 14 (MT1-MMP)IBA
01/2011
1Growth Factor ReceptorsIBA
12/2010
1Trastuzumab (Herceptin)FDA Link
12/2010
1GemcitabineFDA Link
11/2010
1DNA (Deoxyribonucleic Acid)IBA
08/2010
1Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA
08/2010
1TamoxifenFDA LinkGeneric
08/2010
1Tyrosine Kinase InhibitorsIBA
03/2009
1Small Interfering RNA (siRNA)IBA
01/2008

Therapy/Procedure

27Therapeutics
07/2018 - 05/2006
4Drug Therapy (Chemotherapy)
08/2019 - 05/2006
2Intravenous Administration
01/2017 - 07/2016
1Transplantation
01/2020
1Biological Therapy
06/2012
1Combination Drug Therapy (Combination Chemotherapy)
11/2010